If you have a blockage that prevents transportation of sperm, your doctor may recommend surgery to repair this. Section , the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes. It affects the hormone balance within the body and promotes ovulation. A man might have problems with fertility but have no problems with energy or erections, for example. Stress-related cortisol secretion in men: Alpha-adrenergic receptors in the penis:
Saved: Clomid for men with low testosterone part one
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The new study, a phase II clinical trial, will appear in an upcoming issue of the journal Fertility and Sterility. A phase II clinical trial is the second of four phases used to test a drug for safety and effectiveness before it is submitted to the Food and Drug Administration for approval. Low testosterone , or hypogonadism, affects millions of U. Symptoms of the condition include fatigue, loss of muscle mass, an increase in body fat, depression, erectile dysfunction and low libido.
Testosterone levels in men drop naturally after about age 30, but lower-than-normal levels are also associated with obesity, diabetes and circulatory disease. The definition of a normal testosterone level is hotly debated, because it varies so greatly among individuals. However, in general, doctors treat men with low testosterone mainly using testosterone injections and gels. The treatments are expensive, and once they are stopped, testosterone levels plummet.
Lawrence Ross, a urologist and professor emeritus at the University of Illinois at Chicago, who did not work on the new study. One perhaps surprising side effect of current testosterone drugs is low sperm count. The influx of externally produced testosterone causes the brain to tell the testicles to produce less testosterone, which compromises sperm production.
Many primary care physicians do not know about this effect, however, and they readily prescribe testosterone to male patients who have low testosterone and also wish to have a child, said Ross, who wrote an editorial accompanying the new study in the journal. A survey by the American Urological Association found that 25 percent of urologists said they would use testosterone to treat infertile men pursuing pregnancy. Is there any concerns with taking it prior to having an MRI?
It all depends on the patient. Each man is different, and I treat each one according to his specific needs. After reading the post on Clomid, my understanding that this drug is used for men with secondary hypogonadism since it affects the blockage of estrogen at the pituitary. Hi Doug, great question. I have Klinefelters Syndrome. I am using a compounded testosterone.
I was thinking that the estrogen blocking drugs would produce more LH and I already have too much. Hi Doug, I really feel for you. Please read the FAQ. For example, if one were experiencing ED because they had low T, they would want to be able to achieve erections if the Doctor prescribed clomid to address their problem. Testosterone controls many body functions in men and likely in women, and different problems may arise if it is too low. A man might have problems with fertility but have no problems with energy or erections, for example.
Is there a specific time of day you recommend your patients take clomid e. Is there a dose you generally start them on or a certain range you use to start with? I have ready mainly either 25mg or 50mg and wondering if with that dosage its effective at all. Hi Tim, no specific instructions as the half life of the medication is relatively long. You can learn about that and dosing at http: I have 3 questions. When does he stop using the drug? What happens after he stops taking the drug? How does the patient control the increasing estrogen levels?
Hello doctor, I was reading about some studies with clomiphene citrate. What do you think about this, compared to lower doses used in humans? This weight gain cited in the study can be dangerous if it occur in humans? Hi Saulo, see my post on dosing clomiphene here. Hi If someone was born with bilateral undescended testicles that were descended surgically when he had already developed beared and mustaches, and was diagnosed as NOA, had high FSH, high LH and very low T, do you think Clomid or Drugs like anastrozole and testolactone may be of some help in finding few sperms in ejaculate or in mTESE.
Hi Zehra, such a person with such a specific history would best be seen by a qualified doctor who could work with him and prescribe medications as they are needed. Libido, for example, is complex and involves more than just hormones. Sometimes the only way you can figure it out is to correct testosterone and see if the patient improves. If you are a qualified generalist, just like any medication, you can prescribe it with an off-label discussion with your patient, monitor effects, and involve a specialist as the need arises.
I even wrote a post just intended for physicians prescribing the medication. Hi Gregory, if a man has the right or wrong, depending on your point of view genes for it, testosterone converted to dihydrotestosterone at the hair follicle kicks out the hair. So increasing testosterone, which is what clomiphene is intended to do, may accelerate that process. Thanks for this informative post.
Thanks for the blog and the info. I have a question. Have you ever seen—or heard of—a link between clomid in men and hypercoagulation? I took clomid 25mg every 3 days for a few years but recently stopped because I had a serious episode of DVT with a clot in the lung and one in the heart. I have read here and there on the internet about the possibility that in some men clomid spurs production of estrogen, which in turn causes clotting. But these were not expert sources. Also in your research, has it shown that LH and T levels stay consistent after slowly getting off of clomid?
Typically, the two conditions are unrelated. But every man should see a doctor, as everyone is an individual, and all things can happen in nature. Do you know if Clomid can hurt liver function. Is there any research on this drug in regards to liver damage? Just curious, since some drugs are hard on the liver. Any man considering clomiphene should consult his doctor about his overall health.
The body is an intricate interacting system. Nice article, I always wounder how exactly the negative feedback happens.. How long does it normally take for the average male with low T to start seeing results if he started at your beginning dosage of 25mg of Clomid daily? Hi Kevin, the information on how long it takes before a change in the blood level is observed can be found here.
The information on how long it takes to make sperm can be found here. In your experience trying to compare what percentage of SHBG increase do you usually see in patients 90 days out from adding Clomid to their regimen? SHBG increases are rare events. If you are commonly seeing significant increases with clomiphene monotherapy, I would suggest that you submit a report to a journal, preferably in a prospective study.
Testosterone is part of a larger system that includes many parts, which are different in every man. I mention this in several places in this blog: Clomiphene does one of 3 things: Choosing the medication clomiphene and monitoring its effect is between a man and his doctor. And would this mean what was once secondary hypogonadism has become primary if testosterone levels start to fall?
I read this somewhere and just wanted to know if it was true. What seems like a simple question is actually quite complicated: This is exactly why a man needs to see an expert physician in reproductive medicine to evaluate him individually and make recommendations specific to his case. Does Clomiphene have any sway factors when trying to conceive. Are you more likely to have a boy or girl? Does the male body need estrogen? Read the posts on DHT and estradiol.
Estradiol may rise beyond normal. DHT is formed from testosterone in organs such as hair follicles and liver. There, it may increase with increasing testosterone. Yes, the male body needs estrogen. I have concerns about all drugs and patients. Men need to be monitored by their doctors as everyone is different. Any chance you could give me some direction to help me find them? Please read the other posts in this blog and especially the comments of all posts, where I address that question in detail.
Niederberger; Have you heard of any reports connecting Clomid to anorgasmia in men? Each man is unique and responds in a different way to medication. Clomid is proven to raise low sperm counts in men…but by how much? What is the typical improvements according to studies? Clomiphene citrate is not proven to increase sperm counts in men. Nothing in medicine is proven.
What we do instead is to draw a line between increasing testosterone for those who need it and the sperm factory, and it may or may not help. The analogy I use a lot is you have a car that you see from the gas gauge is out of gas and so you fill it up and turn the ignition. It may start if the only problem was an empty tank.
As I commonly write, each man needs to see his doctor to try to figure out what his own particular story is. Thank you for the information on how this works. Is it known from any trials or you knowledge as to when or how long the drugs takes to increase the testosterone, energy, and sex drive? Typically we assess blood levels at 2 weeks, but changes in sperm are expected to take much longer.
Both are written about extensively on this blog. Hi, a question for u. My husband was getting testosterone injections every other week. After a year of injections. He decided to discontinue the injections bc they made no difference. His testosterone levels are He is only Well our dr recommended trying clomiphene. And testing once a month to see if it helped. We want another child and after 3 years of trying this seems like a answer to our prayers.
Does it cause hairloss in men or any birth defects in children? Do u think he would benefit from it. Bc he has no energy and feels awful all the time. Hi Santana, you and your husband really need to see a doctor familiar with male reproductive medicine. You mean testosterone replacement therapy? The general consensus is for side effects related to testosterone, increasing testosterone increases risk.