
Many women are reluctant to take hormone replacement therapy to reduce these because of its link with breast cancer. In this large study, letrozole was not associated with increased risks of serious adverse maternal, fetal, or neonatal outcomes, as compared with the risks in the gonadotropin and clomiphene groups combined. As compared with gonadotropin use, the use of letrozole resulted in lower rates of live birth and multiple gestation, whereas the rates of these outcomes did not differ significantly between letrozole and clomiphene. When she was told about Mr. These results were consistent with the results of the intention-to-treat analysis. When individual groups were compared, the incidence of multiple clinical pregnancy was significantly higher with gonadotropin than with clomiphene or letrozole Table 2 and Figure 1C. In this study of couples with unexplained infertility, the rate of multiple gestation was not significantly reduced among women treated with letrozole for ovarian stimulation, as compared with a combined group of women receiving current standard therapy gonadotropin or clomiphene.