Clomid for women bodybuilding quotes gym

By | 11.02.2018

I've been taking 50mg a day, and I see visible gains and like I mentioned earlier, am able to lift more. Top All times are GMT Clomiphene citrate Clomid was recently reclassified as an SERM because of its ability to compete with estradiol for the estrogen receptors at the level of the hypothalamus [22]. Other SERMs may also be investigated for their potential role in the management of secondary male hypogonadism. Originally Posted by Pacific Rim. Low Dose Clomid Therapy The following study took things further and found Clomid to be effective due to inhibition at the estrogen receptor in the hypothalamus.

The most common treatment of symptomatic late-onset hypogonadism is testosterone therapy with various transcutaneous, buccal, oral, and intramuscular delivery methods [2]. These delivery methods all share a common shortcoming. Because exogenous testosterone formulations cannot mimic the natural endogenous pathway of hypothalamus用ituitary hormonal axis, suppression of the hypothalamic用ituitary揚onadal axis is inevitable via a negative feedback mechanism [2].

Low levels of gonadotropin releasing hormone GnRH , in turn, further decrease production of luteinizing hormone LH and follicular stimulating hormone FSH by the pituitary gland. The reduction in FSH results in suppression of spermatogenesis. These endocrinologic changes are clinically manifested in reduction of both testicular size and sperm count. Moreover, excess testosterone from an external source can be metabolized to estradiol, which can result in gynecomastia. Other reported side effects include inadvertent contact contamination of spouse and children for gels and transdermal patches as well as hepatotoxities for oral formulations.

Hypogonadism in aging is also associated with increased body weight, adipose tissue, and estrogens, resulting from peripheral conversion of testosterone to estradiol. The negative feedback mechanism from excess estradiol results in a paradoxically low LH secretion from the pituitary despite a physiologically low testosterone level. The term secondary hypogonadism most accurately describes the predominant physiological process that occurs with aging [4]. In addition, we will address the applicability of this medication as a therapeutic option for hypogonadism.

Discussion Male aging is associated with progressive decline in androgen production. This phenomenon has been described as andropause, male climacteric, or progressive androgen decline in the aging male. Because men do not experience an abrupt decrease and cessation of male hormone secretion that results in testicular failure, the term andropause is misleading [2]. As men age, alterations in the hypothalamus用ituitary揚onadal axis occur. This directly translates into decreased hypothalamic production of gonadotropins, starting a hormonal cascade resulting in decline of serum testosterone.

Male hypogonadism is a dynamic process that involves multiple organs, similar to the aging process itself. The age-related decline in testosterone is due to defects at all levels of the hypothalamic用ituitary葉esticular axis: This may explain the gradual rise of LH with aging. Perhaps the most dramatic changes occur at the hypothalamus用ituitary axis. The normal circadian rhythm is disrupted, and LH secretion is inhibited by negative feedback mechanism via estradiol.

Increase in visceral fat and obesity have been implicated as key contributors to secondary male hypogonadism [13]. This low testosterone level may be attributed to altered insulin metabolism and resistance as a consequence of decreased muscle mass and increased fat [14]. Testosterone therapy has been used as a treatment for diminished libido and erectile dysfunction in hypogonadal men. The goal of testosterone therapy should be to maintain physiological levels of testosterone.

In addition, it should ideally limit the conversion of testosterone to its metabolites such as dihydrotestosterone and estradiol. This will optimize the positive effects of testosterone, while curbing the side effects of its metabolites. Historically, hypogonadism has been treated with testosterone supplementation. Exogenous therapy with testosterone is the mainstay of therapy, and the emphasis is placed on improving the delivery system. As a result, many different exogenous testosterone preparations are commercially available [2].

They are in oral, injectable, and transdermal formulations. Each one of these delivery systems has advantages and disadvantages. Oral agents such as fluoxymesterone, methylterstosterone, and testosterone undecanoate have the convenience of being given orally. However, they can have significant hepatotoxic and gastrointestinal side effects. Liver function tests must routinely be performed to monitor for these changes. Furthermore, absorption and bioavailability are poor, and these oral testosterone therapy agents are not approved by the Food and Drug Administration FDA [15,16].

Intramuscular formulations of testosterone in cypionate or enanthate were the next products developed. This mode of delivery unfortunately leads to supraphysiological levels of testosterone in the first 72 hours of administration, followed by hypophysiological levels after 1021 days. Obviously, maintenance of the normal circadian pattern of testosterone production is impossible with injectable preparations. There are also some data indicating an increase in hemoglobin levels and hypercoagulopathy associated with intramuscular formulations [19].

Transdermal testosterone therapy was the next generation of products made available. Normal testosterone levels can be maintained by using both types of patches. However, contact contamination to females and children is a major disadvantage with transdermal formulations [2,20,21]. Other side effects include gynecomastia, decreased sperm counts, softening, and decreased size of the testicles.

Clomiphene citrate Clomid was recently reclassified as an SERM because of its ability to compete with estradiol for the estrogen receptors at the level of the hypothalamus [22]. Clomiphene blocks the normal negative feedback of circulating estradiol on the hypothalamus, preventing estrogen from lowering the output of GnRH. We used a relatively low oral daily dose of clomiphene citrate 25 mg in 36 men with a mean age of 39 years.

All patients had low testosterone levels with an average testosterone level of Patients were enrolled and followed prospectively. Serum levels of testosterone, estradiol, FSH, and LH were measured at the time of the initial visit and the first follow-up approximately 46 weeks later. Similar changes were seen in both young and old patients. No patients reported any side effects of clomiphene citrate including gynecomastia and nipple tenderness.

In a recent article by Guay et al. Both LH and free testosterone increased significantly in all patients. The l evels of testosterone have risen more in the men aged more than 40 years vs. Tenover and Bremmer showed that, during a clomiphene challenge, testosterone rose more in younger than in older men. Of course, in their study the age differences were much greater. We cannot give a definite answer, but we can speculate that younger men have often an anxiety component to their low testosterone levels, via making adrenergic substances.

This might be one explanation for the lower testosterone levels in the younger men and would be consistent with some of our anecdotal data [6]. Our study revealed promising results. Clomiphene citrate induces endogenous production of testosterone via competitive blockage of hypothalamic estrogen receptors. This effect presents a unique therapeutic opportunity for the management of hypogonadism in the aging male.

Low dose, oral therapy with minimal side effects is an excellent substitute to transdermal or injectable testosterone alternatives. It enhances the endogenous androgen synthesis pathway while maintaining the natural circadian rhythm. This method of treatment is especially important in hypogonadal men with infertility, who wish to father children. Exogenous testosterone therapy suppresses spermatogenesis and the hypothalamic用ituitary葉esticular axis and may cause testicular atrophy.

We understand that hypogonadism in aging males affect older patients. This phenomenon is usually caused by a combination of primary and secondary hypogonadism. Clomiphene citrate may offer an easy and practical solution for a subset of older patients with hypogonadism. Because this is a heterogeneous group of patients, we do not expect the same response in all older patients. This does not change the fact that clomiphene citrate might be an excellent option for some men, especially those where secondary hypogonadism is a major component of their problem.

Our future work will focus on the older patients with hypogonadism. There are obvious limitations to this pilot study. Further investigation is needed to confirm the effectiveness of clomiphene citrate for the treatment of androgen deficiency in secondary male hypogonadism. Studies are needed to determine the optimal dose response in different age groups. Validated measurements of muscle strength, weight, sexual function, exercise tolerance, bone density, and mood changes are required before accepting clomiphene citrate as a standard of care for secondary hypogonadism.

Long-term safety and efficacy data are not available, as well as clomiphene citrate effects on lipid metabolism. Lastly, other SERMs may function in a manner similar to clomiphene citrate and may also have benefits. However, an improvement of sexual symptoms was described by Guay et al. Share this post Link to post Share on other sites. The efficacy of oral clomiphene citrate CC in the treatment of male hypogonadism and male infertility MI with low serum testosterone and normal gonadotropin levels has been reported.

Serum values were collected 12 months after treatment initiation and semi-annually thereafter. Retrospective data collection was performed via chart review. Average age years was 42 CC vs. Average follow up was 23 months CC, range 840 months vs. Average pretreatment ADAM sexual function domain score was 0. There were no adverse events reported. CC represents a treatment option for men with hypogonadism, demonstrating biochemical and clinical efficacy with few side effects and lower cost as compared with TGRT.

Discussion The past decade has seen significant advancements in the study and understanding of male hypogonadism and the natural hormonal changes of the aging male [79]. Using Clomid alone, not for post-cycle For 3 weeks I've been using clomid as a testosterone amplifier, and it definately works by itself For example, the week before I did it, I could barely shoulder press 2 70 pound dumbells for 6 reps.

But now I can hit 10 reps of 70 and even did 5 of I've been starting to become depressed and moody, and its to the point that I'm loosing my appetite and my ambition to go to the gym. Has anyone had this experience with clomid? The emotional effects has been linked with clomid usage before. I am not too aware with the appetite suppression though.

I guess appetite suppression might be related more with the "depressing" effects that you say you have rather than with clomid itself. I've been medicated to treat a "natural" depression, and one of the things that helped to diagnose my depression was a big appetite suppression I could make through a day with just a coffee in my stomach. I can't really compare clomid to other anti-estrogens because its really the only drug I've used for bodybuilding.

I've been natural for years, trying occasional prohormones that did nothing but make me edgy. I've been taking 50mg a day, and I see visible gains and like I mentioned earlier, am able to lift more. I think I'm going to ride it out for another week, but I'm getting way too depressed! I thought that I'd be happier making all this progress!


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