Those with liver qi stagnation or heat sympsoms will also be more susceptible to experiencing to the side effects headaches, stomach upset, abnormal bleeding , but not the therapeutic benefits, of this drug. Further, if the person with damaged yin already hot and dry with a constitutional blood or yin vacuity, takes a yang invigorating drug, there is much greater chance of failure during the Clomid stimulated cycle. Their body cannot properly adapt to the yang invigorating effects in such a manner as to support a pregnancy.
All they will get is the side effects. It will work against fertility. Who then, should receive Clomid? According to Chinese Medicine, the only patients who would respond favorably to Clomid are those patients desiring pregnancy who have a kidney yang vacuity, spleen qi vacuity, cold and dampness in the uterus. Pergonal Pergonal menotropins for injection, USP , by Serono Laboratories is a purified preparation of gonadotropins extracted from the urine of postmenopausal women.
Human Chorionic Gonadotropins hCG , a naturally occurring hormone in post-menopausal urine, is detected in Pergonal. Pergonal administered for seven to twelve days produces ovarian follicular growth in women who do not have primary ovarian failure. Treatment with Pergonal in most instances results in follicular growth and maturation. In order to effect ovulation, hCG must be given following the administration of Pergonal when clinical assessment of the patient indicates that sufficient follicular maturation has occurred.
Pergonal and hCG given in a sequential manner are indicated for the induction of ovulation and pregnancy in the anovulatory infertile patient, in whom the cause of anovulation is functional and is not due to primary ovarian failure. Adverse reactions during Pergonal therapy incloude pulmonary and vascular complications, hemoperitoneum, adnexal torsion, ovarian cysts, flu like symptoms, nausea, vomiting, diarrhea, abdominal cramps, bloating, body rashes, dizziness, tachycardia, dyspnea, and tachypnea.
Pergonal is also a yang invigorating, warming medicinal. It has the same effects as Clomid. It will receive greater therapeutic benefit from those that are not deficient in yin, and from those whose qi is not obstructed. If you are deficient in yin or fit the diagnostic pattern for qi stagnation, follow the dietary guidelines for your specific pattern treatment. Do the exercises listed above. Follistim Follistim follitropin beta for injection, either subcutaneously or intramuscularly, is manufactured by Organon.
It contains human follicle-stimulating hormone hFSH , a glycoprotein hormone which is manufactured by recombinant DNA technology. Follitropin beta is synthesized in a Chinese hamster ovary cell line that has been transfected with a plasmid containing the two subunit DNA sequences encoding for hFSH. Follistim stimulates ovarian follicular greowth in women who do not have primary ovarian failure. FSH, the active component of Follistim, is required for normal follicular growth, maturation, and gonadal steroid production.
In the female, the level of FSH is critical for the onset and duration of follicular development and consequently for the timing and number of follicles reaching maturity. In order to effect the final phase of follicle maturation, resumption of meiosis and rupture of the follicle in the absence of an endogenous LH surge, human chorionic gonadotropin hCG must be given following the administration of Follistim when patient monitoring indicates that appropriate follicular development parameters have been reached.
Overstimulation of the ovary may occur with the use of Follistim as well. Like Pergonal, adverse reactions include miscarriage, ovarian hyperstimulation syndrome, ectopic pregnancy, abdominal pain, injection site pain, and vaginal hemorrhage. Also included were dizziness, tachycardia, dyspnea, tachpnea, febrile reactions, flu-like symptoms including fever, chills, musculoskeletal aches, joint pains, nausea, headache and malaise, breast tenderness and dermatological symptoms such as dry skin, body rash, hair loss and hives.
These symptoms, as well, mimic the symptoms of qi rectifying, yang invigorating medicinals. We, therefore, include Follistim in the category of drugs which stimulate the yang and raise the yang qi. This drug will provide greater therapeutic benefit to those that are not deficient in yin, and from those whose qi is not obstructed. It is a purified preparation of gonadotropins, extracted from the urine of postmenopausal females and possess follicle stimulating hormone and luteinizing hormone activity.
The ratio of FSH bioactivity and LH bioactivity in menotropins is adjusted to approximate unity by the addition of human chorionic gonadotropin purified from the urine of pregnant women. Humegon and hCG are given in a sequential manner for use in inducting ovulation and pregnancy in the anovulatory infertile woman. Humegon is categorized according to Chinese Medicine, as Clomid, Pergonal, and Follistim are, as a yang invigorating medicinal.
Gonal F Gonal F, follitropin alpha for injection, by Serono Laboratories, is a human follicle stimulating hormone preparation of recombinant DBA origin, which stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of Gonal F is the primary hormone responsible for follicular recruitment and development.
In order to effect final maturation of the follicle and ovulation in the absence of an endogenous LH surge, hCG must be given following the administration of Gonal-F when monitoring of the patient indicates that sufficient follicular development has occurred. There is interpatient variability in response to FSH administration.
The physicochemical, immunological, and biological activities of recombinant FSH are comparable to those of pituitary and human menopausal urine-derived FSH. Overstimulation of the ovary may occur, as well as multiple births, and the same yang invigorating effects of the above classified medicinals. If you are categorized as yin deficient, or fit the diagnostic pattern for qi stagnation, follow the dietary guidelines for your specific pattern treatment.
Pregnyl Pregnyl, by Organon, Inc. HCG is a polypeptide hormone produced by the human placenta, composed of an alpha and a beta subunit. The alpha sub-unit is essentially identical to the alpha sub-units of the human pituitary gonadotropins, LH and FSH, as well as to the alpha sub-unit of human thyroid stimulating hormone. The beta subunits of these hormones differ in amino acid sequence. Pregnyl is a highly purified pyrogen free preparation obtained from the urine of pregnant females.
It stimulates the production of gonadal steroid hormones by stimulating the corpus luteum of the ovary to produce progesterone. Pregnyl is used to induce ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure and who has been appropriately pretreated with menotropins above. HCG should be used in conjunction with human menopausal gonadotropins only by physicians experienced with infertility problems who are familiar with the criteria for patient selection, contraindications, warmings, precautions, and adverse reactions which include: Its indications, uses, and energetic category is the same as other yang invigorating medicinals.
Those with vacuous yin or qi stagnation should develop a yin supplementing of qi rectifying program to improve this drug's therapeutic effect. The analog possesses greater potency than the natural hormone. Lupron acts as a potent inhibitor of gonadotropin secretion when given continuously and in therapeutic doses. Following an initial stimulation, chronic administration of Lupron results in suppression of ovarian steroid production.
This effect is reversible upon discontinuation of drug therapy. In humans, subcutaneous administration of single daily doses of Lupron results in an initial increase in circulation levels of LH and FSH, leading to a transient increase in levels of the gonadal steroids estrone and estradiol. In premenopausal females, estrogens are reduced to post-menopausal levels. These decreases occur within two to four weeks after initiation of treatment. Lupron produces numerous side effects including cardiovascular symptoms like congestive heart failure, ECG changes, ischemia, high blood pressure, murmur, peripheral edema, phlebitis, and thrombosis.
GI symptoms include anorexia, constipation, nausea, and vomiting. Lupron can also cause anemia, bone pain, myalgia, dizziness, lightheadedness, headache, insomnia, sleep disorders, dyspnea, sinus congestion, dermatitis, urinary frequency and urgency, hematuria, urinary tract infection, and asthenia. Lupron is also used therapeutically for prostatic cancers, precocious puberty, endometriosis, and leiomyomas.
When treating infertility, it is often used to suppress the normal production of FSH, LH, and estrogens, so that control of the above hormones may be maintained without the patient's own hormones interfering with the medically controlled hormonal stimulation. Since Lupron inhibits estrogen or yin, it often has signs and symptoms of yin vacuity and vacuity heat like hot flashes, night sweats, and headaches.
Headaches are typically located behind the eye or eyes, and in the back of the head and neck, which corresponds to heat rising along the urinary bladder meridian in Chinese medicine. When Lupron fails to down regulate a patient who is undergoing an assisted reproductive cycle, their estrogen levels remain elevated and their endometrium typically remains too thick. Since these women are not responding to the hormonal down-regulation of Lupron, they typically are not allowed to finish the assisted reproductive protocol and thereby receive the hormonally stimulating medication.
Estrogen clearing in Traditional Chinese Medicine can be accomplished through clearing the liver channel with acupuncture and herbs. Vigorous stimulation to certain acupuncture points, every other day, employing such points as Lv 2 moving between , Lv 3 great rushing , Lv14 cycle gate , and LI 4 joining valley , can bring a woman's estrogen levels down to the desired range within just a few treatments.
Herbal treatment aimed at clearing the liver channel can also assist in accomplishing this effect. To bring on the woman's period, the same points can be used, assisted by points such as Sp6 three yin intersection , GB21 shoulder well , and Sp10 sea of blood. Blood invigorating medicinals are added to this regimen as well to help bring on the period. Of utmost importance is the long-term effects of hormonal stimulation. The hormonal stimulating drugs which compel the ovaries to produce more eggs have the long-term energetic effect of depleting the essence of the kidney.
This becomes more important as a woman is nearing forty years or older, and her reproductive energies are beginning to decline. It is therefore wise to give your body a break between hormonal cycles to recover the kidney essence. It is very important to keep your reproductive endocrinologist abreast of the complementary measures you are employing concurrently with his procedures. Communication between you and your physician will allow you to trust that everything that you are doing for yourself will only enhance the reproductive medical protocol.
Nothing in this book should be practiced if you have any misgivings about your doctor's position on these techniques. Unless you have your doctor's blessing, you should not take over-the-counter herbal preparations during hormonal stimulation. There is great potential for interaction with herbal medicine and hormonal stimulation. Rhonda didn't marry until she was She knew immediately that she wanted to try to have a family, and she and Robert began trying immediately.
When, after six months, they were not successful, they went on to more aggressive treatments. Her doctor performed a Clomid challenge test on her, to assess what the ovarian response to the hormonal medication would be. Her FSH levels were drawn on day 3 of her cycle. They were higher than normal. She took Clomid for five days and the FSH levels were taken again to see if the increased or decreased. Hers increased; she "failed" the test. She came to see me. Hers was the typical scenario of a woman trying to conceive in her forties.
Diminished ovarian reserve due to kidney vacuity. She was developing signs of kidney yin and liver blood vacuity - sore low back, night sweats, vaginal dryness, visual changes, and hair loss. As soon as we started to make a difference in these symptoms, she was anxious to see if she could proceed with hormonal stimulation. She took another Clomid challenge test with another reproductive endocrinologist, and this time "passed.
I didn't believe her ovaries had time to adjust to the hormonal effects and were not yet producing "healthy" quality eggs. She was going to go through one last IVF cycle, and give it her all. She went on a diet consisting of only pure, macrobiotic, organic foods, and nutritionally pure substances. She took kidney yin and yang tonifying herbs every day for the next three months.
She took a leave of absence from her job. She diminished the stress in her life; her new job became maximizing her fertility. She meditated, she got massages, she took yoga classes. We worked on improving the blood supply to her ovaries and uterus with acupuncture. She had a fabulous response to the medication, typical of a much younger woman. She became pregnant during her 43rd year, and gave birth to a baby girl when she was Sherry was referred to me by her reproductive endocrinologist when she was She previously had poor response to hormonal stimulation, and produced a maximum of three follicles during her past attempts at IVF.
Each cycle was cancelled. Sherry had contracted pelvic inflammatory disease many years prior, and had to undergo extensive abdominal surgeries for fallopian tube obstruction and resulting adhesions. Her fallopian tubes had been removed. When a diagnostic doppler ultrasound was eventually performed, the blood flow to her ovaries was shown to be severely impeded. Sherry was already scheduled for her next IVF procedure, and was already on oral contraceptives to control her hormones. We had only a few weeks in which to maximize her response.
I performed electroacupuncture on the paraspinal muscles of her low back at the levels between vertebras L1 and S2 which supply the sympathetic innervation to the uterus and ovaries. By stimulating these areas and the same dermatomal patterns on the lower legs, I was giving her brain the message to "turn down" the sympathetic control of the pelvic organs.
When the sympathetic response lessens, the blood vessels dilate and supply more blood to the organs, delivering more hormonal stimulation to the ovaries, and improving the uterine blood flow. Sherry was also extremely anxious. Her palms were sweaty, she was depondent and scared about her poor response to the IVF cycles. Although she did not describe herself as irritable or depressed, stress had become a large part of her poor response. I taught her some qi gong breathing and meditative visualization techniques, and taught her husband the femoral massage technique to perform three times per day on Sherry.
During each acupuncture visit, I performed the back acupuncture treatment on her, followed by the "de-stressing" treatment, applying stimulation to the point between the eyebrows, the point on the top of the feet one inch up from the web between the first and second toes, and the point on the hands, in the muscular tissue one inch up from the web between the thumb and first finger. I also applied stimulation to the uterus and ovarian points on the lower abdomen.
When she began injecting the drugs, Sherry and her husband reported that her mental response to the hormonal stimulation was much improved and she felt calmer, almost peaceful. She was accepting of the outcome this time, no matter what the results. The response was dramatic. Her reproductive endocrinologist reported that the doppler studies revealed a great improvement in ovarian blood flow. Nine eggs were retrieved, six fertilized, and two implanted.
Both were carried to almost term, and they are the proud parents of twins, one boy and one girl. Do not smoke, use nicotine patches or chew nicotine gum. Do not drink any alcohol. Do not drink any coffee. Eat well, according to your pattern discrimination dietary guidelines. Exercise daily before an IVF transfer, but do not perform jarring, high impact or heavy weight lifting exercises which make you grunt and raise the internal abdominal pressure gradient.
Before and during hormonal stimulation, perform the exercises which directly increase blood flow to the pelvic organs: Breathe in very deeply, and concentrate on bringing your breath from your nose and down the midline of your body, between the breasts, down the abdomen, and eventually focusing your breath down to the region two inches below your navel.
This is called the Dan Tien. Let the breath energy pool here. At the end of inhalation, bring the focus from the area below your navel down through the uterus and to the perineal muscles. Now perform a kegel exercise, squeezing the perineal muscles as if you were attempting to stop the flow or urine. When you release the kegel, begin exhalation. During exhalation, turn the focus of your attention from the tip of the coccyx and up the spine to the top of the head, then down the midline of the head and out the nose.
Repeat steps 1, 2, and 3, until they become one smooth, continuous movement. Women who fail to down regulate during Lupron therapy are effectively not clearing estrogen. Rhonda's Roa Rhonda didn't marry until she was Sherry Sherry was referred to me by her reproductive endocrinologist when she was Reduce stress hormones that interfere with ovulation 2. Normalize hormones that regulate ovulation so an egg is released 3. Increase blood flow to the uterus, improving the chances of a fertilized egg implanting 4.
Evgeniya Rodina, , No. Timea Babos, , , No. Ons Jabeur, , No. Jelena Jankovic, 3 , No. Pauline Parmentier, 61, No. Ekaterina Alexandrova, , Arina Rodionova def. Monica Puig, , , Petra Martic def. Mona Barthel, , Varvara Lepchenko def. Saisai Zheng, , No. Oceane Dodin, , Day 3, Wednesday, July 5 recap. Beatriz Haddad Maia, , No. Francesca Schiavone, , No. Donna Vekic, 4 , , No.
Jennifer Brady, , No. Qiang Wang, , , Madison Brengle def. Francois Abanda Victoria Azarenka def. Camila Giorgi Heather Watson def. Ana Bogdan, , Naomi Osaka def. Irina-Camelia Begu, 3 , , Day 4, Thursday, July 6 recap. Kirsten Flipkens, , Magdalena Rybarikova def. Tsvetana Pironkova, , No. Ekaterina Makarova, , No. Christina McHale, , 7 , Alison Riske def. Yanina Wickmayer, , No. Kristina Kucova, , No. Tatjana Maria, , Anett Kontaveit def.
Day 5, Friday, July 7 recap. Shuai Peng, , 7 No. Carina Witthoeft, , No. Naomi Osaka, 3 , No. Camila Giorgi, , No. Madison Brengle, , Victoria Azarenka def. Heather Watson, , , Day 6, Saturday, July 8 recap. Shelby Rogers, , 2 , No. Anett Kontaveit, , 3 , No. Polona Hercog, , No. Sorana Cirstea, , No.